Interacts with 5-hydroxytryptamine receptor type I, located in the smooth muscle walls of blood vessels of the brain, selectively constricts blood vessels in the carotid system, inhibits the activity of the trigeminal nerve. All this contributes to reducing the severity of pain in migraine. The clinical effect is observed after 30 minutes.
When administered masterone is rapidly absorbed. 70% of the maximum serum concentration achieved after 45 minutes. The average value of the absolute bioavailability is 14% due to first-pass metabolism and incomplete absorption. The degree of binding to plasma proteins is low (14-21%), half-time – 2 hours. The major metabolite (indole acetic analogue of masterone) appears mainly in the urine as free acid and its glucuronide conjugate.
Indications for use:
Relief of acute attacks of migraine (with aura or without).
Dosage and administration:
Inside. The tablet is swallowed whole with water. For adults: a single dose of 0.05 g, in some cases – 0.1, the maximum daily dose of 0.3 g If migraine symptoms do not disappear or diminish after the first dose, the second dose for the relief of the same attack appoint do not do it. If symptoms diminished or gone, and then resumed again, you can take a second dose within the next 24 hours. The interval between doses is at least 2 hours.
Individual intolerance to the drug, coronary heart disease, angina pectoris; hemiplegic, basilar or oftalmoplegicheskaya forms of migraine, PCC lyuzionnye peripheral artery disease, uncontrolled arterial giperten-sity; stroke or transient ischemic attack in history; liver failure, pregnancy, lactation, infancy, old age (over 65 years), with the simultaneous use of ergotamine and its derivatives. Precautions – epilepsy (including any condition with reduced epileptic threshold), hypertension (controlled ), concomitant use of drugs, MAO inhibitors, and up to 14 days after their cancellation.
The sensation of tingling, heat, heaviness, pressure, or in different parts of the body flushing of the skin and mucous membranes; dizziness, fatigue, weakness, drowsiness; attack steno-cardia, hypotension, tachycardia, palpitations, transient increase in blood pressure, transient ischemic ECG changes such as bradycardia, and in rare cases – Raynaud’s syndrome; discomfort in the abdomen, dysphagia, nausea, vomiting, ischemia-cal colitis; visual disturbances (diplopia, scotoma, blurred vision); Allergic reactions: rash, urticaria, pruritus, erythema, anaphylaxis: changes in liver function tests; myalgia.
Amigrenin should not be used prophylactically. Before the appointment of masterone in patients with newly diagnosed migraine or atypical flowing, should exclude other potentially threatening neurological disease. It must be borne in mind that in patients suffering from migraine headaches, there is a risk of stroke or transient ischemic attacks. It should not be used in patients with suspected heart disease without prior examination. The first 2-3 hours of the drug should be under a doctor’s supervision (possible spasm of the coronary arteries). In patients with hypersensitivity to sulfonamides when administered masterone there is an increased risk of allergic reactions (from cutaneous manifestations to anaphylactic shock). If there is no effect on the administration of the first dose, it is necessary to specify the diagnosis. Experience with masterone in patients over 65 years of age is limited (no significant difference in the pharmacokinetics compared to younger patients not observed). Since the application Amigrenin can cause drowsiness, use caution when driving and operating machinery.
In case of overdose, the patient should be monitored for 10 hours, symptomatic therapy if necessary.
Drug Interactions: Invalid simultaneous reception: preparations containing ergot alkaloids; drugs lithium; inhibitors of reverse neuronal capture of serotonin-se; MAO inhibitors.
In 2 or 10 tablets in blisters; 1 contour cellular packaging with instructions for use in a pack. In 2 or 10 tablets in a jar of glass lighting. Each bank together with instructions for use in a pack. steroiden kaufen
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