masteron propionate

Pharmacological action masteron propionate (the active metabolite of bromhexine) is a mucolytic drug that improves the rheological properties of sputum, reducing its viscosity and adhesive properties, which contributes to its removal from the airways.
masteron propionate stimulates the activity of serous cells of bronchial tubes glands, production of enzymes that break down the relationship between sputum polysaccharides , the formation of surfactant and directly activity of the cilia of the bronchi, preventing them from sticking together.
After oral administration, the therapeutic effect occurs within 30 minutes and lasts for 6-12 hours (depending on the dose).

Ambrobene – Solution for oral and inhalation is used for diseases of the respiratory tract with separation of viscous sputum and difficulty sputum discharge:
– acute and chronic bronchitis, pneumonia;
– asthma,
– bronchiectasis.

– Hypersensitivity to masteron propionate and / or other components of the formulation,
– gastric ulcer and duodenal ulcer;
– epileptic syndrome

Relative contraindications
By limiting the functional ability of the kidneys and / or severe liver disease Ambrobene should be taken with extreme caution, reducing the applied dose and increasing the time between doses of the drug (normally under these conditions treatment is carried out under the supervision of a physician).
With great caution and only under medical supervision Ambrobene should be applied in cases dysmotility bronchi and large amounts of allocated secret (the danger of stagnation secretion in the bronchi).

Use during pregnancy and lactation
Despite the fact that to date there is no reliable data about the negative effects of masteron propionate on the fetus and infants, use Ambrobene during pregnancy, especially in the I trimester and during lactation is possible only after a thorough analysis of benefit / risk ratio attending physician.

DOSAGE AND ADMINISTRATION The use of inside: Inside Ambrobene drug is taken after a meal with a sufficient quantity of liquid (eg, water, juice or tea) using the supplied measuring cup. The following dosage commonly used (1 mL of solution contains 7.5 mg of masteron propionate): Children up to 2 years taking 1 ml, 2 times a day (15 mg / day). Children aged 2 to 6 years taking 1 ml three times a day (22.5 mg / day). Children aged 6 to 12 years by taking 2 ml of solution 2-3 times a day (30-45 mg / day). Adults and adolescents in the first 2-3 days of treatment taking 4 ml 3 times per day (90 mg / day) during the following days 4 ml solution, 2 times a day (60 mg / day). inhalation: When applying Ambrobene by inhalation can be any equipment (excluding steam inhalation). Before inhalation, the drug is mixed with 0.9% sodium chloride solution (for optimal humidification can be diluted in the ratio 1: 1) and heated to body temperature. Inhalation should be performed in the usual mode of breathing (not to provoke cough shock). Patients suffering from bronchial asthma, in order to avoid non-specific respiratory irritation and spasm before the inhalation of masteron propionate should be used bronchodilators. Typically, use the following dosage (1 mL of solution contains 7.5 mg of masteron propionate): Children under 2 years old inhaled by 1 ml 1-2 times a day (7.5-15 mg / day). Children from 2 to 6 years 2 ml of solution 1-2 times a day (15-30 mg / day). children older than 6 years and adults inhaled by 2.3 ml 1-2 times a day (15-45 mg / day). children to Treatment 2 years carried out only under the supervision of a physician. in the recommended drinking plenty of fluids while taking Ambrobene drug. It is not recommended to use Ambrobene without a doctor’s appointment more than 4-5 days.


Occasionally can develop weakness, headache, dry mouth and airways, excessive salivation, rhinorrhea, gastralgia, nausea, vomiting, diarrhea, constipation, dysuria, rash. In very rare cases there may be allergic reactions (rash, angioedema person, respiratory failure, temperature reaction with chills). It has been reported that in some cases were observed allergic contact dermatitis, and in one case observed the occurrence of anaphylactic shock.

Concomitant use with drugs having antitussive activity (eg, containing codeine) is not recommended because of difficulties removing phlegm from the bronchial tubes in the background to reduce coughing.
Co-administration with antibiotics (amoxicillin, cefuroxime, erythromycin, doxycycline) improves pulmonary delivery of antibiotics in the way. Such interaction with doxycycline widely used for therapeutic purposes.

masteron propionate is well tolerated when administered at a dose of 25 mg / kg per day. Symptoms: increasing saliva, nausea, vomiting, decreased blood pressure. Treatment: gastric lavage in the first 1-2 hours after taking the drug, taking fat-containing products; necessary to monitor the hemodynamics and holding, if necessary, symptomatic therapy.

dark glass bottles containing 40 ml or 100 ml of the product, with cork-dropper and screw cap. 1 bottle with enclosed measuring cup and information to consumers in a cardboard box. mexican steroids for sale uk steroid can you buy steroid nasal sprays over the counter

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masteron dosage

Pharmacological properties masteron dosage relates to inhibitors of fibrinolysis, a synthetic lysine analogues. By its action is similar to epsilon-aminocaproic acid, but it is much more efficient.Specific hemostatic effect AMBENA bleeding caused by an increase in fibrinolysis, due to the blockade of plasminogen activators and partial inhibition of the effect of plasmin. masteron dosage inhibits fiber-noliz competitively saturating the lysine-binding receptors, through which binds to fibrinogen (fibrin) Plaza lamprey (plasmin). The drug also inhibits biogenic polypeptides kinins.
masteron dosage enhances the detoxifying function of the liver, inhibits the antibody response.
For internal administration the maximum concentration of drug in the blood is determined immediately after the injection and lasts up to 3 hours. masteron dosage displayed by the kidneys: 60% -80% unchanged. In case of violation of renal excretory function AMBENA concentration in the blood increases significantly.



  • states in which the system develops hyperfibrinolysis (overdose plasminogen activators: streptokinase, urokinase, etc.);
  • with a decrease in the ability of the formation of a hemostatic clot (in violation of procoagulant, platelet or vascular hemostasis components);
  • when localized hemorrhages due to increased local fibrinolytic activity (after tonsillectomy, operations on the prostate, bladder, menorrhagia).
  • in surgical procedures and different pathological processes with increased fibrinolytic activity of the blood; brain surgery (including with subarachnoid hemorrhage), lung, heart surgery, vascular, thyroid, and pancreas; after dental procedures, with premature detachment of normally situated placenta, a long delay in the cavity of a dead fetus of the uterus, uterine bleeding; acute pancreatitis; liver disease; bow, gastro-intestinal bleeding.
  • preventing the development of secondary hypofibrinogenaemia when massive transfusion of banked blood.Contraindications
    Tendency to thrombosis and thromboembolic disorders, hypersensitivity, hypercoagulable phase of DIC. vitreous hemorrhage, severe coronary heart disease and cerebral ischemia, diseases of the kidney with a violation of their functions, pregnancy and lactation.
    Precautions to apply for violations of cerebral circulation!Dosage and administration:
    Inject intravenously in doses of 50-100 mg (5-10 ml of 10 mg / ml).
    If necessary, the administration can be repeated several times at intervals of not less than 4 hours. In acute fibrinolysis is further added fibrinogen, controlling blood fibrinolytic activity, and fibrinogen content in it. The maximum single dose is 100 mg (10 ml of 10 mg / ml solution). Total (daily) dose and duration of treatment depend on the disease.

    Side effect From the digestive system: vomiting, diarrhea. From the CCC : increase or decrease in blood pressure, tachycardia. Local reactions: thrombophlebitis at the injection site. Allergic reaction. Other:. Renal colic, catarrhal phenomena from the upper respiratory tract were observed in some cases dizziness, orthostatic hypotension, seizures. This should reduce the dose or stop the drug.

    of drug overdose is extremely rare and is characterized by increased blood clotting. If you need to overdose intravenous heparin at a dose of 5000 ME and / or removal of the drug.

    The interaction with other drugs
    simultaneous use of large doses Ambena and other hemostatic agents (eg. Etamzilata) can lead to blood clots, on the one hand, by increasing the formation of fibrin by the action of hemostatics, and on the other hand, due to the slow dissolution of the formed thrombus due antiplazminovogo Ambena action.

    use of the drug requires a check fibrinolytic activity of blood and fibrinogen level. Intravenously, the need to control coagulation, especially coronary heart disease, myocardial infarction, liver diseases.
    Introduction AMBENA can be combined with the introduction of hydrolysates, especially glucose solution, antishock solutions. When acute fibrinolysis is further added fibrinogen (average of the last dose – 2 – 4 r max – r 8).

    Product form
    The solution for intravenous administration of 10 mg / ml in 5 ml ampoules. 5 vials in the cell package of PVC film. On 2 stripes package together with instructions for use in a pile of cardboard boxed.

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masteron enanthate

Pharmacological properties masteron enanthate is a bifunctional alkylating agent belonging to chloroethylamino group. The process consists in the alkylation covalent svyazshanii formed of two bis-2-chloroethyl group carbon intermediates with guanine in position 7 and the DNA cross-linking of two DNA strands, resulting in the disruption of cell replication. Active against quiescent and actively dividing tumor cells. Pharmacokinetics Absorption of the drug when administered incomplete and variable: the time of detection of drug in plasma ranges from 0 to 336 minutes (due to the variable absorbability in the digestive tract, the rapid hydrolysis and the presence of the effect of “first pass” through the liver ) and concentration peak value – from 70 to 630 ng / ml. The bioavailability ranges from 25% to 89%, averaging 61%. Upon receiving masteron enanthate oral dose of 0.2-0.25 mg / kg body weight of the maximum plasma concentration (87-350 ng / ml) was observed after 0.5-2,0 hours Connection to plasma proteins -. 60-90%, about 30 % binds irreversibly. The volume of distribution – 0.5 l / kg. It is metabolized to inactive metabolites in body fluids and tissues. The average half-life -. 1.12 hr ± 0.15 When receiving Alkeran tablets directly after a meal time to reach maximum concentration increases, and the area under the curve ( “Plasma concentration – time”) is reduced by 39-45%. Excreted by the kidneys – 50% (10-15% unchanged), with faeces – 20-50%. Not removed by hemodialysis.


  • multiple myeloma
  • Advanced ovarian cancer
  • polycythemia vera


  • Hypersensitivity to masteron enanthate and other components of the tablets.
  • Pregnancy and lactation

Precautions: condition after radiotherapy, preceded cytostatic therapy, anemia, leukopenia (white blood cell count below 2000 cells / mm), thrombocytopenia (less than 50,000 / microliter), chickenpox, herpes zoster and other infections, end-stage disease;. heavy comorbidities: parenchymal hepatitis, arthritis, gout, urate nephropathy, nephritis and diseases of the cardiovascular system in the stage of decompensation.

Dosing and Administration
Inside. When receiving the tablets should not be divided into parts.
The absorption of oral masteron enanthate after variable. If necessary, the dose can be gradually increased until myelosuppression characteristics so as to provide therapeutic concentration of the drug. Multiple myeloma Generally, the dose is 0.15 mg / kg body weight per day (taken in divided doses) for 4 days at intervals of 6 weeks. For more information on using other regimens is recommended to refer to the literature. In some regimens further include prednisolone, which increases the effectiveness of the treatment compared with monotherapy Alkeran, combination therapy is usually performed intermittent courses. Long-term therapy over one year does not improve results. ovarian cancer progressing Generally, the dose is 0.2 mg / kg of body weight per day for 5 days. Courses are repeated every 4-8 weeks or whenever the recovery of bone marrow function. Polycythemia for remission induction drug typically administered at a dose of 6-10 mg / day. for 5-7 days, then dose reduced to 2.4 mg / day. to achieve a therapeutic effect. For maintenance therapy, the drug is prescribed in a dose of 2-6 mg once a week. Use in children Alkeran in the usual range of doses used in children only rarely, so the specific dosing recommendations are not available. Use in elderly patients Alkeran is frequently used in elderly persons age in the general range of doses, with caution due to a possible reduction in kidney, liver, heart, and simultaneously the therapy of opportunistic diseases. Special information for use in patients in this age group do not have the drug. Use in patients with renal insufficiency clearance Alkeran in renal failure can be reduced. Existing data on the pharmacokinetics does not support the absolute need to reduce the dose Alkeran in patients with renal impairment, but it is advisable in the early stages of treatment to determine its tolerability in the therapy reduced doses. Patients in this case should be kept under close supervision. The starting dose is adjusted to the clearance of creatinine; subsequent doses determined in accordance with the response from the peripheral blood.

Side effect On the part of hematopoiesis: leukopenia, thrombocytopenia, rarely – anemia. On the part of the liver and the digestive system: nausea, vomiting (30%), diarrhea, stomatitis, gastric ulcer and duodenal ulcer (the risk of these side effects is greatly enhanced during combined tsytostaticheskoy therapy), rarely – liver dysfunction, clinically manifested hepatitis or jaundice. Allergic reactions: hives, swelling, skin rash, anaphylactic shock. The respiratory system: rarely – interstitial pneumonitis and pulmonary fibrosis. Other: hyperuricemia, seldom – alopecia very rarely – hemolytic anemia. Perhaps the development of amenorrhea and azoospermia. Patients with the original signs of renal failure in patients receiving masteron enanthate in the early stages of treatment a marked transient increase urea levels in blood serum. Against the background of leukopenia / neutropenia may develop secondary infections. Melfapan (like other antitumor alkylating agents) during prolonged use can cause the development of acute leukemia.
The most likely early manifestations of acute overdose Alkeran ingestion are disorders of the gastrointestinal tract, including nausea, vomiting and diarrhea. The main toxic effect of masteron enanthate is to suppress the bone marrow with the development of leukopenia, thrombocytopenia and anemia. Treatment – symptomatic. There is no specific antidote. Careful monitoring of peripheral blood counts for at least 4 weeks after the overdose until there are signs of normalization.

Interaction with other medicines and other forms of interaction
Co-administration with nalidixic acid in children can lead to death due to the development of hemorrhagic enterocolitis.
Chlorpromazine, chloramphenicol and sodium metamizole mielodepressivnogo increase the severity of the action.
Cisplatin induced renal failure and reduces the clearance of masteron enanthate. Cyclosporin and high doses of masteron enanthate are a potentially dangerous combination because of the possible development of renal dysfunction (itself nephrotoxic drug does not possess).
In simultaneous reception with live virus vaccines is possible intensification of the process of replication of vaccine virus, increasing its side / adverse effects and / or reduction of antibody in the patient in response to the vaccine.


Alkeran should be used only under the supervision of a physician who is experienced in the use of anticancer drugs.
Since Alkeran is a potent myelosuppressive agent, it is necessary to carry out regular monitoring of blood cell composition in order to prevent possible development of excessive myelosuppression and the risk of irreversible bone marrow aplasia. The number of blood cells may continue to fall after discontinuation of the drug, so at the first sign too sharp decline in the number of white blood cells or platelets, treatment should be temporarily discontinued.
Alkeran should be used with caution in patients who recently have undergone radiation therapy or chemotherapy, for the opportunity to gain toxic effect on bone marrow.
in appointing the patients with multiple myeloma and related chronic renal failure may be a temporary increase in urea in the plasma.
For the prevention of hyperuricemia is recommended to drink plenty of liquids, alkalizing urine drugs, allopurinol.
Need refusal of immunization (if it is not approved by the physician in the range of 3 months to 1 year after drug administration).; other members of the patient’s family, residing with him, should abandon immunization oral polio vaccine (to avoid contact with people who received the polio vaccine or wearing a protective mask that covers the nose and mouth).
If you use Alkeran should implement the recommendations on the use of cytotoxic drugs.
Women and men during treatment with Alkeran and for at least 3 months. after it should use reliable methods of contraception. steroids for building muscle oral steroids for sale where can i buy steroid cream creatine bodybuilding supplement alpha pharma primo best multivitamins for men bodybuilding

masteron cycle

Pharmacological action masteron cycle – local anesthetic used in ophthalmology. The action usually occurs after 20-30 seconds after instillation and lasts for 15 minutes or longer.
masteron cycle inhibits cell membrane permeability to sodium ions, which prevents the generation of impulses in the nerve endings and the conduction of impulses along nerve fibers. Pharmacokinetics When applied topically, systemic absorption is low.

Local anesthesia in ophthalmology for short-term diagnostic and therapeutic procedures that require quick and short-term anesthesia cataract surgery, suture removal of the cornea or conjunctiva; tonometry, Gonioscopy; removal of foreign bodies from the cornea; conjunctival scraping for diagnostic purposes.

Individual hypersensitivity to the drug.

Use with caution in patients with allergic reactions, heart disease and gipetireoidizmom.

Application of pregnancy and lactation
have sufficient experience of use of the drug during pregnancy, breastfeeding and have no children. Perhaps the use of the drug in children, during pregnancy and lactation to destination the attending physician, if the expected therapeutic effect is greater than the risk of possible side effects.

Dosing and Administration
Locally. When performing tonometry and other short duration procedures instilled 1-2 drops, immediately before the procedure. For small surgical procedures (removal of foreign body or suture removal) instilled drops every 1-2 minutes 5-10 (1-3 doses).
If necessary, prolonged anesthesia (in cataract extraction) – 5-10 drops every 1-2 minutes ( 3-5 doses). After the surgical procedure is necessary to cover the bandage the eyes because ‘blink’ reflex temporarily eliminated.

Side effects are
usually well tolerated. You may experience itching, burning and redness of the conjunctiva; . lacrimation or rapid blinking
rare and usually immediately after instillation may experience severe allergic reactions such as epithelial keratitis; corneal erosion, filamentary infiltrates the cornea, iritis. Prolonged use may more slow healing of wounds. It should be borne in mind the possibility of long-term use of systemic toxicity (which is shown by stimulation of the central nervous system, with subsequent inhibition), although the use of the drug as a topical anesthetic in such a reaction it is rarely possible.

Data on overdose of the drug available.

Interaction with other drugs
Data on drug interactions are absent.

Specific guidance
is important for the entire period of anesthesia to protect the eye from being hit by irritating chemicals, foreign bodies, and do not rub the eye. Patients should be warned that they do not touch your eyes, until after the effect of the anesthetic. The vial must be closed after each use. Do not touch the pipette tip to the eye.

Product form
solution (ocular drops) in «Droptainer flakonah- » LDPE 15 ml. 1 bottle with instruction on the medical application in a carton box.

Shelf life of
30 months. After opening the vial the drug should be used within 4 weeks.
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Combination drug whose action is due to its constituent active ingredients. Aspirin has analgesic, antipyretic anti-inflammatory effect, which is caused by the inhibition of cyclooxygenase enzymes involved in prostaglandin synthesis. Aspirin inhibits platelet aggregation by blocking the synthesis of thromboxane A 2 .Sodium carbonate neutralizes free hydrochloric acid in the stomach, which reduces the irritant effect of the drug. Citric acid promotes more rapid absorption of the drug.

Symptomatic treatment of pain: headache (including after excessive alcohol consumption), toothache, sore throat, back pain and muscle pain, joint pain, pain during menstruation.
Increased body temperature in cold and other infectious and inflammatory diseases (adults and children over 15 years).


  • Hypersensitivity to aspirin and other NSAIDs or other components of the drug;
  • erosive and ulcerative lesions of the gastrointestinal tract (exacerbation);
  • hemorrhagic diathesis;
  • the combined use of methotrexate at a dose of 15 mg per week or more;
  • asthma, caused by intake of salicylates or other NSAIDs;
  • pregnancy (I and III trimester), lactation.The drug is not indicated for children under 15 years old with acute respiratory infections caused by viral infections, because of the risk of Reye syndrome (encephalopathy and acute fatty liver with development of acute liver failure).Be wary – when concomitant therapy with anticoagulants, gout, stomach ulcers and / or duodenal ulcer (in history), including chronic or recurrent course of ulcer disease or episodes of gastrointestinal bleeding; renal and / or hepatic insufficiency, deficiency of glucose-6-phosphate dehydrogenase;Dosing and Administration
    The drug is intended for adults and children over 15 years.
    Inside, adults and children over 15 years: Take 1 tablet up to 6 times per day. When severe pain and high temperature – 2-3 masteron; the maximum daily dose should not exceed 9 masteron (3 g).
    How to use: dissolve the tablet / masteron in a glass (200 ml) of water. The frequency and reception time interval between doses of the drug should be at least 4 hours. Regular adherence of the drug to avoid a sharp increase in temperature and decrease in pain intensity.

    The duration of treatment (without consulting a doctor) should not exceed 5 days when administered as an analgesic, and more than 3 days – as an antipyretic.

    Side effect On the part of the gastrointestinal tract: abdominal pain, heartburn, nausea, vomiting, explicit (vomiting blood, tarry stools) or hidden signs of gastrointestinal bleeding, which can lead to iron deficiency anemia, erosive and ulcerative lesions (including including perforation) of the gastrointestinal tract, are isolated cases – liver function abnormalities (elevated liver transaminases). On the part of the central nervous system: dizziness, tinnitus (usually a sign of overdose). from the hematopoietic system: increasing the risk of bleeding, which is a consequence of the effect of aspirin on platelet aggregation.Allergic reactions: skin rash, anaphylactic reactions, bronchospasm, angioedema. If you notice such symptoms should stop taking the drug immediately and contact your doctor.


    Symptoms of
    overdose of moderate severity: nausea, vomiting, tinnitus, hearing loss, headache, dizziness and confusion. These symptoms are at lower doses.

    Severe overdose: fever, hyperventilation, ketosis, respiratory alkalosis, metabolic acidosis, coma, cardiogenic shock, respiratory failure, severe hypoglycaemia.

    Treatment: hospitalization, lavage, activated charcoal method, monitoring of acid-base balance, alkaline diuresis in order to get the urine pH between 7.5-8 (forced alkaline diuresis is achieved if the salicylate concentration in plasma is greater than 500 mg / l (3.6 mmol / l) in adults or 300 mg / l (2.2 mmol / l) in children), hemodialysis, fluid loss compensation, symptomatic therapy.

    Interaction with other drugs

    Joint application: with methotrexate 15 mg per week or more: increased hemolytic cytotoxicity of methotrexate (decreased renal clearance of methotrexate and methotrexate replaced salicylates in relation to plasma proteins) with anticoagulants, such as heparin: increased risk of bleeding due to inhibition of platelet function, mucosal lesions of the gastrointestinal tract, the displacement anticoagulants (oral) in connection with plasma proteins, other non-steroidal anti-inflammatory drugs as well as with large doses of salicylates (3 g per day or more) as a result of synergistic interaction, and increased risk of ulcers and bleeding, with urikozuratami example benzbromaron: reduces uricosuric effect; with digoxin: the concentration of digoxin increased due to decreased renal excretion, with antidiabetic agents such as insulin: increased hypoglycemic effect of antidiabetic agents due to hypoglycemic action of acetylsalicylic acid with drugs group thrombolysis: the risk of bleeding is increased ; diuretics in dose of 3 mg per day and more: reduced glomerular filtration due to a decrease of prostaglandin synthesis; systemic corticosteroids, excluding hydrocortisone used as replacement therapy in Addison’s disease: the application of glucocorticosteroids reduces salicylates blood by increasing the excretion latter; with angiotensin-converting enzyme: at a dose of 3 g per day and more reduced glomerular filtration by inhibition of prostaglandins, and as a consequence, reduced the antihypertensive effect; valproic acid: increased toxicity of valproic acid with ethanol: the risk of the damaging effect on the mucous gastro -kishechnogo tract and increases bleeding time.

  • CautionsAspirin can cause bronchoconstriction, bronchial asthma attack or other hypersensitivity reactions.
    The risk factors are the presence of asthma, nasal polyps, fever, chronic obstructive lung diseases, cases of allergy in the anamnesis (allergic rhinitis, skin rash).
    Aspirin may increase the tendency to bleeding, due to its inhibitory effect on platelet aggregation. This should be considered as necessary surgical procedures, including small interfering as tooth extraction.Before surgery to reduce bleeding during surgery and in the postoperative period, the drug should be discontinued for 5-7 days and put in a doctor’s reputation.
    Children should not be prescribed drugs containing acetylsalicylic acid because the risk of Reye’s syndrome is increased in the case of a viral infection. Symptoms of Reye syndrome are prolonged vomiting, acute encephalopathy, liver enlargement. If necessary, use during lactation should stop breastfeeding.
    In the treatment of cardiovascular disease daily dose of acetylsalicylic acid is from 75 to 300 mg.
    Acetylsalicylic acid reduces the excretion of uric acid from the body, which can cause an acute attack of gout in susceptible patients.
    One effervescent Alka-Seltzer tablet contains 445 mg of sodium, which should be considered when a diet with a controlled sodium intake.
    There was no influence of the drug in the management of vehicles and other mechanisms.Form release
    2 effervescent masteron in a strip of paper, laminated with foil; 5 strips together with instructions for use in a carton box. On 10 effervescent masteron in a strip of paper, laminated with foil; 1 and 2 strips together with instructions for use in a carton box.

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