Combination drug whose action is due to its constituent active ingredients. Aspirin has analgesic, antipyretic anti-inflammatory effect, which is caused by the inhibition of cyclooxygenase enzymes involved in prostaglandin synthesis. Aspirin inhibits platelet aggregation by blocking the synthesis of thromboxane A 2 .Sodium carbonate neutralizes free hydrochloric acid in the stomach, which reduces the irritant effect of the drug. Citric acid promotes more rapid absorption of the drug.
Symptomatic treatment of pain: headache (including after excessive alcohol consumption), toothache, sore throat, back pain and muscle pain, joint pain, pain during menstruation.
Increased body temperature in cold and other infectious and inflammatory diseases (adults and children over 15 years).
- Hypersensitivity to aspirin and other NSAIDs or other components of the drug;
- erosive and ulcerative lesions of the gastrointestinal tract (exacerbation);
- hemorrhagic diathesis;
- the combined use of methotrexate at a dose of 15 mg per week or more;
- asthma, caused by intake of salicylates or other NSAIDs;
- pregnancy (I and III trimester), lactation.The drug is not indicated for children under 15 years old with acute respiratory infections caused by viral infections, because of the risk of Reye syndrome (encephalopathy and acute fatty liver with development of acute liver failure).Be wary – when concomitant therapy with anticoagulants, gout, stomach ulcers and / or duodenal ulcer (in history), including chronic or recurrent course of ulcer disease or episodes of gastrointestinal bleeding; renal and / or hepatic insufficiency, deficiency of glucose-6-phosphate dehydrogenase;Dosing and Administration
The drug is intended for adults and children over 15 years.
Inside, adults and children over 15 years: Take 1 tablet up to 6 times per day. When severe pain and high temperature – 2-3 masteron; the maximum daily dose should not exceed 9 masteron (3 g).
How to use: dissolve the tablet / masteron in a glass (200 ml) of water. The frequency and reception time interval between doses of the drug should be at least 4 hours. Regular adherence of the drug to avoid a sharp increase in temperature and decrease in pain intensity.
The duration of treatment (without consulting a doctor) should not exceed 5 days when administered as an analgesic, and more than 3 days – as an antipyretic.
Side effect On the part of the gastrointestinal tract: abdominal pain, heartburn, nausea, vomiting, explicit (vomiting blood, tarry stools) or hidden signs of gastrointestinal bleeding, which can lead to iron deficiency anemia, erosive and ulcerative lesions (including including perforation) of the gastrointestinal tract, are isolated cases – liver function abnormalities (elevated liver transaminases). On the part of the central nervous system: dizziness, tinnitus (usually a sign of overdose). from the hematopoietic system: increasing the risk of bleeding, which is a consequence of the effect of aspirin on platelet aggregation.Allergic reactions: skin rash, anaphylactic reactions, bronchospasm, angioedema. If you notice such symptoms should stop taking the drug immediately and contact your doctor.
overdose of moderate severity: nausea, vomiting, tinnitus, hearing loss, headache, dizziness and confusion. These symptoms are at lower doses.
Severe overdose: fever, hyperventilation, ketosis, respiratory alkalosis, metabolic acidosis, coma, cardiogenic shock, respiratory failure, severe hypoglycaemia.
Treatment: hospitalization, lavage, activated charcoal method, monitoring of acid-base balance, alkaline diuresis in order to get the urine pH between 7.5-8 (forced alkaline diuresis is achieved if the salicylate concentration in plasma is greater than 500 mg / l (3.6 mmol / l) in adults or 300 mg / l (2.2 mmol / l) in children), hemodialysis, fluid loss compensation, symptomatic therapy.
Interaction with other drugs
Joint application: with methotrexate 15 mg per week or more: increased hemolytic cytotoxicity of methotrexate (decreased renal clearance of methotrexate and methotrexate replaced salicylates in relation to plasma proteins) with anticoagulants, such as heparin: increased risk of bleeding due to inhibition of platelet function, mucosal lesions of the gastrointestinal tract, the displacement anticoagulants (oral) in connection with plasma proteins, other non-steroidal anti-inflammatory drugs as well as with large doses of salicylates (3 g per day or more) as a result of synergistic interaction, and increased risk of ulcers and bleeding, with urikozuratami example benzbromaron: reduces uricosuric effect; with digoxin: the concentration of digoxin increased due to decreased renal excretion, with antidiabetic agents such as insulin: increased hypoglycemic effect of antidiabetic agents due to hypoglycemic action of acetylsalicylic acid with drugs group thrombolysis: the risk of bleeding is increased ; diuretics in dose of 3 mg per day and more: reduced glomerular filtration due to a decrease of prostaglandin synthesis; systemic corticosteroids, excluding hydrocortisone used as replacement therapy in Addison’s disease: the application of glucocorticosteroids reduces salicylates blood by increasing the excretion latter; with angiotensin-converting enzyme: at a dose of 3 g per day and more reduced glomerular filtration by inhibition of prostaglandins, and as a consequence, reduced the antihypertensive effect; valproic acid: increased toxicity of valproic acid with ethanol: the risk of the damaging effect on the mucous gastro -kishechnogo tract and increases bleeding time.
- CautionsAspirin can cause bronchoconstriction, bronchial asthma attack or other hypersensitivity reactions.
The risk factors are the presence of asthma, nasal polyps, fever, chronic obstructive lung diseases, cases of allergy in the anamnesis (allergic rhinitis, skin rash).
Aspirin may increase the tendency to bleeding, due to its inhibitory effect on platelet aggregation. This should be considered as necessary surgical procedures, including small interfering as tooth extraction.Before surgery to reduce bleeding during surgery and in the postoperative period, the drug should be discontinued for 5-7 days and put in a doctor’s reputation.
Children should not be prescribed drugs containing acetylsalicylic acid because the risk of Reye’s syndrome is increased in the case of a viral infection. Symptoms of Reye syndrome are prolonged vomiting, acute encephalopathy, liver enlargement. If necessary, use during lactation should stop breastfeeding.
In the treatment of cardiovascular disease daily dose of acetylsalicylic acid is from 75 to 300 mg.
Acetylsalicylic acid reduces the excretion of uric acid from the body, which can cause an acute attack of gout in susceptible patients.
One effervescent Alka-Seltzer tablet contains 445 mg of sodium, which should be considered when a diet with a controlled sodium intake.
There was no influence of the drug in the management of vehicles and other mechanisms.Form release
2 effervescent masteron in a strip of paper, laminated with foil; 5 strips together with instructions for use in a carton box. On 10 effervescent masteron in a strip of paper, laminated with foil; 1 and 2 strips together with instructions for use in a carton box.