masteron steroid

The drug has expectorant, mucolytic action. Reduced sputum viscosity occurs as a result of depolymerization of mucopolysaccharides, which are in the sputum.The depolymerization of mucopolysaccharides related primarily to break disulfide bonds in their molecules, masteron steroid increases motor activity of ciliated epithelium, increases mucociliary transport, normalizes the ratio of serous and mucous components of phlegm. By activating the hydrolyzing enzymes and increasing the release of lysosomes of cells Clarke, reduces the viscosity of sputum. It facilitates the removal of mucus from the respiratory tract. masteron steroid stimulates the prenatal development of the lungs by increasing the synthesis and secretion of surfactant in the alveoli. Synthesis of surfactant decreases as a result of chronic diseases of the respiratory system, in addition, the surfactant properties are changed by the formation of linkages between the surface-active phospholipids and inflammatory proteins.

Pharmacokinetics
Absorption – high, time to maximum concentration – 0.5 – 3 hours, connection with blood plasma proteins – 80-90%, penetrates the blood-brain barrier, placental barrier, excreted in breast milk.
The drug is metabolized in the liver to inactive metabolites (dibromantranilovoy and glucuronic acid conjugates). The half-life (T 1/2 ) – from 7 to 12 hours. Excreted by the kidneys: 90% in the form of metabolites, 10% unchanged.

Indications
Acute and chronic respiratory diseases with separation of viscous sputum: acute and chronic bronchitis, chronic obstructive pulmonary disease, pneumonia, bronchial asthma with obstruction of sputum discharge, bronchiectasis; treatment and prevention of respiratory distress syndrome.

Contraindications
: Hypersensitivity to the drug, pregnancy (I term).

Precautions
The drug should be used with caution in patients with gastric ulcer and duodenal ulcers, as can occur exacerbation of peptic ulcer disease, and in patients with renal and hepatic insufficiency.

Use during pregnancy and lactation:
The drug is not recommended for use during the I trimester of pregnancy. If necessary, the use of masteron steroid in II-III trimesters of pregnancy should evaluate the potential benefits for the mother and the possible risk to the fetus.

During the period of breast-feeding to use the drug with caution, because it is excreted into breast milk.

Dosage and Mode of application Adults: 2-3 days 2-3 times daily for two scoops (2-3 x 30 mg masteron steroid), and then – 2 times a day for two scoops. In severe cases, the dose is not reduced during the course of treatment. The maximum dose – 2 times a day for 4 scoops (2 x 60 mg). Children aged 5 to 12 years: appoint 2-3 times a day for 1 measuring spoon (2-3 × 15 mg masteron steroid). Children aged 2 to 5 years: prescribed 3 times daily 1/2 measuring spoon (3 x 7.5 mg masteron steroid). Children under 2 years: appoint 2 times daily 1/2 measuring spoon ( 2 times but 7.5 mg of masteron steroid). Children under 2 years AmbroGEKSAL® administered only under medical supervision. AmbroGEKSAL® should be taken after meals. During the treatment it is necessary to use a lot of liquid (juice, tea, water) to enhance mucolytic effect of the drug. The duration of treatment depends on the severity of the disease and is determined by the attending physician. Without the advice of a doctor should not take longer than 4-5 days AmbroGEKSAL®.

Side effects From the digestive system: nausea, vomiting, gastralgia, diarrhea, constipation, dry mouth. Allergic reactions: skin rash, urticaria, angioedema, bronchospasm attack, fever with chills, very rare (<0.01%) – anaphylactic shock. Rarely (<1%): fatigue, headache, runny nose, increased salivation, dry airways, impaired urination (dysuria). due to the presence of sodium metabisulphite (a preservative), may develop hypersensitivity reactions (especially in patients with asthma), which manifest themselves in the form of vomiting, diarrhea, acute asthma attacks, violation of consciousness or shock. These reactions can occur very individual, but also lead to life-threatening consequences.

Overdosing
Symptoms: nausea, vomiting, gastralgia. There are reports of the appearance of short-term anxiety and diarrhea. In severe overdose, possible fall in blood pressure. Treatment: artificial vomiting, gastric lavage in the first 1-2 hours after taking the drug, taking zhirosodsrzhaschih products.

Interaction with other medicinal products
In the application with antitussive drugs possible difficulty sputum discharge as a result of the suppression of the cough reflex. With simultaneous use with amoxicillin, cefuroxime, erythromycin, doxycycline masteron steroid increases their concentration in bronchial secretions.

Cautions
masteron steroid should not be taken simultaneously with antitussive drugs that can inhibit the cough reflex, such as codeine, as This may hinder the removal of liquefied sputum from the bronchial tree.
AmbroGEKSAL® should be used with caution in patients with impaired cough reflex or impaired mucociliary transport patients because of the possibility of accumulation of phlegm.
Patients taking masteron steroid should not recommend performance of breathing exercises; in severely ill should perform aspiration of liquefied sputum.
Patients with asthma may enhance the cough masteron steroid.
Do not take ambroksol just before bedtime. how much to inject for weight loss

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