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masteron only cycle

Neuroleptic from the group of phenothiazines. It has antipsychotic and sedative effect. Reduces or eliminates delusions and hallucinations, relieves agitation reduces affective reactions, anxiety, restlessness, reduces motor activity. It has antiemetic effect. When used in high doses may cause hypnotic effect. It causes extrapyramidal disorders, raises prolactin. It has alpha adrenoblokiruyuschey, protivogistaminnoy and weak m-anticholinergic activity, lowers blood pressure. The mechanism of action of the drug is not completely understood. It is believed that many of the central effects due to blockade of dopamine receptors in various brain regions. Sedation, apparently, due to blockade of the central adrenergic receptors.

Pharmacokinetics

After oral masteron only cycle is rapidly absorbed from the gastrointestinal tract. Bioavailability – about 50%. poluraspredeleniya period of several hours. It is metabolized in the liver to form both active and inactive metabolites. The half-life sufficiently long (4 weeks or more). Return with urine and feces. It penetrates the blood-brain barrier, wherein the concentration of masteron only cycle in the brain than its concentration in plasma.

Indications

  • chronic paranoid and hallucinatory-paranoid state;
  • state of agitation in patients with schizophrenia (hallucinatory-delusional, hebephrenic, catatonic syndromes);
  • alcoholic psychosis, manic agitation in patients with manic-depressive psychosis;
  • mental disorders in patients with epilepsy;
  • agitated depression in patients with presenile, manic-depressive psychosis;
  • neurotic diseases accompanied by increased muscle tone;
  • pain, including causalgia (in combination with analgesics);
  • sleep disorders resistant nature (in combination with hypnotics and tranquilizers);
  • Meniere’s disease;
  • vomiting of pregnancy;
  • treatment and prevention of emesis in the treatment with anticancer agents and radiotherapy;
  • pruritic dermatoses;
  • in the “lytic mixtures” in Anesthesiology

dosage

The mode set individually. For adults, a daily dosage of 25-600 mg; maximum single dose – 300 mg; the maximum daily dose – 1.5 g

Babies administered in a daily dose of 1 mg / kg body weight.

Side effect

Perhaps: hypotension, tachycardia, dyspepsia, dry skin, decrease in salivation.

Rarely (with prolonged use at high doses): neuroleptic syndrome, long-term depression, extrapyramidal disorders; pigmentation of the skin, cataract; allergic reactions.

In isolated cases: toxic hepatitis, agranulocytosis, thrombophlebitis.

Contraindications

  • of the liver and / or kidney problems;
  • dysfunction of hematopoiesis;
  • progressive system of the brain and spinal cord diseases;
  • myxedema;
  • decompensated heart defects;
  • thromboembolic disease;
  • late stage of bronchiectasis;
  • coma;
  • brain injury

special instructions

With caution, under careful control should be prescribed with cholelithiasis and urolithiasis, acute pyelitis, rheumatism, rheumatic heart disease.

Aminazin not recommended for stomach ulcers and duodenal ulcers. With long-term use of the drug are needed to monitor patterns of peripheral blood, prothrombin index, liver and kidney function, neurological examination and consultation ophthalmologist. In experimental studies have shown embryotoxic effects of the drug.

Drug interactions

masteron only cycle increases the effects of hypnotics, opioid analgesics, funds for general and local anesthesia. Action anticonvulsants under the influence of masteron only cycle increases, but in some cases can cause convulsions Aminazin phenomenon. Incompatible with MAO inhibitors. Undesirable long combination with analgesics, antipyretics.

release Form

10 pellets of 50 mg
to 500 mg of pellets 50
10 dragee 100 mg
400 mg 100 dragee androxin

masteron prop

Combination drug whose action is due to its constituent components: the antidepressant masteron prop and anxiolytic chlordiazepoxide. It has a pronounced anti-depressant and anxiolytic effects.

The mechanism of action is based on masteron prop inhibition of reuptake of norepinephrine and serotonin. in the CNS; chlordiazepoxide – is determined by the stimulation of benzodiazepine receptors supramolecular GABA-benzodiazepine-hlorionofor prescription complex, resulting in the activation of GABA receptor, causes a decrease in the excitability of the subcortical structures of the brain, spinal reflexes polysynaptic braking.

Pharmacokinetics of
Orally reception Amiksida maximum plasma concentrations are attained within 4-8 hours. (Because masteron prop slows down the transit time in the digestive tract, absorption can be slowed down, especially in overdose). masteron prop binds to the plasma protein at 94%; the half-life of about 20h. Chlordiazepoxide bound to plasma proteins by 96%; the half-life of about 10h. Both components are metabolized in the liver. The half-life of the active metabolite of masteron prop (noratriptilina) is 80 hours. The half-life of the active metabolite of chlordiazepoxide (desmethyl-chlordiazepoxide) is 1-4 days.

The drug crosses the placental barrier and is excreted in breast milk.

Indications
Apply strictly prescribed by a doctor.
Depression different genesis, the structure of which there is a disturbing syndrome of varying severity.

Contraindications
Acute intoxication from drugs, have a depressing effect on the central nervous system

 

  • Decompensated heart defects.
  • Acute and recovery phase of myocardial infarction.
  • conduction disorders of the heart muscle.
  • Acute liver and kidney disease, with severe dysfunction.
  • Hyperthyroidism and simultaneous treatment of thyroid-stimulating drugs.
  • Peptic ulcer and 12 duodenal ulcer in the acute stage.
  • Angle-closure glaucoma.
  • Prostate Hypertrophy.
  • Atony of the bladder.
  • Pyloric stenosis, paralytic ileus.
  • Simultaneous treatment of MAO inhibitors.
  • Severe myasthenia gravis.
  • Pregnancy, lactation.
  • Childhood.
  • Hypersensitivity to any component of the drug.

 

Be wary – absence (petit mal) or Lennox-Gastaut syndrome; epilepsy or seizures in history, liver and / or kidney failure, cerebral and spinal ataxia, hyperkinesis, a tendency to abuse of psychotropic drugs, organic brain disease (possible paradoxical reactions), hypoproteinemia, advanced age.

Dosing and Administration
Assign inside (after eating), the dose can be set individually.

The initial daily dose – 12.5 1 tablet / 5mg 2-3 times daily. If necessary, the dose can be increased up to 6 mg 25/10 tablets a day for 2-3 hours.

Upon receipt of proof of antidepressant effect in 2-4 weeks the dose gradually and slowly reduced. In the case of depression symptoms at lower doses need to go back to the previous dose.

If the patient’s condition does not improve within 3-4 weeks of treatment, further treatment is not practical.

In elderly patients with pulmonary disorders in outpatient practice, doses of up to 12.5 / 5 mg; 25/25 or 5mg / 10mg usually 1 time per day at night.

Side effects
are mainly related to the anticholinergic effect of the drug, paresis of accommodation, blurred vision, increased intraocular pressure, dry mouth, constipation, ileus, urinary retention, increase in body temperature. These effects usually disappear after adaptation to the drug or dose reduction.

CNS: headache, ataxia, fatigue, weakness, irritability, dizziness, tinnitus, drowsiness or insomnia, impaired concentration, nightmares, dysarthria, confusion, hallucinations, motor agitation, confusion, tremor, paresthesia, peripheral neuropathy, changes in the EEG. Rarely – extrapyramidal disorders, convulsions, anxiety.

Cardio-vascular system: tachycardia, arrhythmias, conduction disturbances, labile blood pressure, expansion of the QRS complex on the ECG (violation of intraventricular conduction), symptoms of heart failure, syncope.

On the part of the digestive tract: nausea, vomiting, heartburn, anorexia, stomatitis, taste disturbances, dark tongue, epigastric discomfort, gastralgia, increased activity of “liver” transaminases. rarely cholestatic jaundice, diarrhea

From endocrine system: an increase in the size of the mammary glands in men and women, galactorrhea, changes in the secretion of antidiuretic hormone (ADH), changes in libido, potency. Rarely – hypo- or hyperglycemia, glycosuria, glucose intolerance, swelling of the testicles.

Allergic reactions: skin rash, pruritus, photosensitivity, angioedema, urticaria.

Other: agranulocytosis, leukopenia, eosinophilia, thrombocytopenia, purpura and other changes in the blood, hair loss, swollen lymph nodes, weight gain during prolonged use, sweating, pollakiuria, muscle weakness.

With prolonged treatment, especially in high doses, the sudden cessation of treatment may develop withdrawal symptoms: headache, nausea, vomiting, diarrhea, and irritability, sleep disturbance with bright, unusual dreams, irritability.

Overdose
Drowsiness, depression of consciousness of varying degrees of severity up to coma, confusion, dysarthria, psychomotor agitation, hallucinations, numbness, seizures, muscle stiffness, vomiting, arrhythmia, hypotension, heart failure, respiratory depression.

aid measures: Amiksidom cessation of therapy, gastric lavage, infusion fluid, detoxification, the introduction of physostigmine 1-3 mg every 1 / 2-2 hours / m or / in, symptomatic therapy, blood pressure and maintaining water and electrolyte balance. Displaying prolonged observation since recurrence of symptoms of intoxication can occur within 48 hours.

Interaction with other drugs
The drug is advisable to use in monotherapy, as masteron prop and chlordiazepoxide combination in combination with other medications in many cases it may be unpredictable.

Active components included in Amiksid potentiate CNS depression following medicines: antipsychotics, sedatives and hypnotics, anticonvulsants, analgesics, anesthetics, alcohol.

In a joint application Amiksida with neuroleptics, and / or anticholinergic drugs can cause febrile temperature reaction, paralytic ileus.

Active components included in Amiksid potentiate the hypertensive effects of catecholamines, but inhibit the effects of drugs acting on the release of noradrenaline (turamin).

Active components included in Amiksid may block the antihypertensive effect of guanethidine and drugs with a similar mechanism of action.

At simultaneous reception Amiksida and cimetidine may increase the concentration of masteron prop in plasma.

Simultaneous reception Amiksida with MAO inhibitors can be fatal. Break in treatment between the intake of MAO inhibitors and tricyclic antidepressants should not be less than 14 days!

Cautions
masteron prop in doses above 150 mg / day reduces the threshold for seizure activity, therefore it is necessary to take into account the possibility of seizures in patients with such a history and a category of patients who are predisposed to it due to age or injury.

Amiksin treatment in the elderly should take place under strict control, with minimal doses and gradually increase them, in order to avoid the development of delirium disorders, hypomania, and other complications.

Patients with depressive phase of manic-depressive syndrome can go to the manic phase.

In renal / hepatic failure and prolonged treatment is necessary to monitor the pattern of peripheral blood and “liver” enzymes.

The risk of drug dependence increases when using large doses, a significant duration of treatment in patients who previously abused alcohol or drugs. should not be used long-term without specific instructions.

It is unacceptable abrupt discontinuation of treatment because of the risk of “withdrawal syndrome”

During reception Amiksida prohibited from driving vehicles, machinery maintenance and other work requiring high concentration. Running low dose t3 clen cycle trying to lose bodyfat isn’t a real hot idea imo.

masterone

Interacts with 5-hydroxytryptamine receptor type I, located in the smooth muscle walls of blood vessels of the brain, selectively constricts blood vessels in the carotid system, inhibits the activity of the trigeminal nerve. All this contributes to reducing the severity of pain in migraine. The clinical effect is observed after 30 minutes.

When administered masterone is rapidly absorbed. 70% of the maximum serum concentration achieved after 45 minutes. The average value of the absolute bioavailability is 14% due to first-pass metabolism and incomplete absorption. The degree of binding to plasma proteins is low (14-21%), half-time – 2 hours. The major metabolite (indole acetic analogue of masterone) appears mainly in the urine as free acid and its glucuronide conjugate.

 

Indications for use:

Relief of acute attacks of migraine (with aura or without).

Dosage and administration:

Inside. The tablet is swallowed whole with water. For adults: a single dose of 0.05 g, in some cases – 0.1, the maximum daily dose of 0.3 g If migraine symptoms do not disappear or diminish after the first dose, the second dose for the relief of the same attack appoint do not do it. If symptoms diminished or gone, and then resumed again, you can take a second dose within the next 24 hours. The interval between doses is at least 2 hours.

 

Contraindications:

Individual intolerance to the drug, coronary heart disease, angina pectoris; hemiplegic, basilar or oftalmoplegicheskaya forms of migraine, PCC lyuzionnye peripheral artery disease, uncontrolled arterial giperten-sity; stroke or transient ischemic attack in history; liver failure, pregnancy, lactation, infancy, old age (over 65 years), with the simultaneous use of ergotamine and its derivatives. Precautions – epilepsy (including any condition with reduced epileptic threshold), hypertension (controlled ), concomitant use of drugs, MAO inhibitors, and up to 14 days after their cancellation.

Side effect:

The sensation of tingling, heat, heaviness, pressure, or in different parts of the body flushing of the skin and mucous membranes; dizziness, fatigue, weakness, drowsiness; attack steno-cardia, hypotension, tachycardia, palpitations, transient increase in blood pressure, transient ischemic ECG changes such as bradycardia, and in rare cases – Raynaud’s syndrome; discomfort in the abdomen, dysphagia, nausea, vomiting, ischemia-cal colitis; visual disturbances (diplopia, scotoma, blurred vision); Allergic reactions: rash, urticaria, pruritus, erythema, anaphylaxis: changes in liver function tests; myalgia.

Special instructions:

Amigrenin should not be used prophylactically. Before the appointment of masterone in patients with newly diagnosed migraine or atypical flowing, should exclude other potentially threatening neurological disease. It must be borne in mind that in patients suffering from migraine headaches, there is a risk of stroke or transient ischemic attacks. It should not be used in patients with suspected heart disease without prior examination. The first 2-3 hours of the drug should be under a doctor’s supervision (possible spasm of the coronary arteries). In patients with hypersensitivity to sulfonamides when administered masterone there is an increased risk of allergic reactions (from cutaneous manifestations to anaphylactic shock). If there is no effect on the administration of the first dose, it is necessary to specify the diagnosis. Experience with masterone in patients over 65 years of age is limited (no significant difference in the pharmacokinetics compared to younger patients not observed). Since the application Amigrenin can cause drowsiness, use caution when driving and operating machinery.

 

 

Overdose:

In case of overdose, the patient should be monitored for 10 hours, symptomatic therapy if necessary.

 

Drug Interactions: Invalid simultaneous reception: preparations containing ergot alkaloids; drugs lithium; inhibitors of reverse neuronal capture of serotonin-se; MAO inhibitors.

 

Product form:

In 2 or 10 tablets in blisters; 1 contour cellular packaging with instructions for use in a pack. In 2 or 10 tablets in a jar of glass lighting. Each bank together with instructions for use in a pack. steroiden kaufen

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masteron side effects

Mucolytic agent. It has sekretomotornym, sekretoliticheskim and expectorant action; stimulates serous cells of glands of bronchial mucosa, increases the amount of mucous secretion and release of a surface-active substance (surfactant) in the alveoli and bronchi; normalizes impaired ratio of serous and mucous components of phlegm. By activating the hydrolyzing enzymes and increasing the release of lysosomes of Clara cells, reduces the viscosity of sputum. It increases motor activity of ciliated epithelium, increases mucociliary transport.

Once inside the action occurs within 30 minutes.

Pharmacokinetics

Absorption – high (if any routes of administration), time to maximum concentration (TC max ) – h 2, connection with plasma proteins – 80%. It penetrates through the blood-brain barrier, placental barrier, excreted in breast milk.

It is metabolized in the liver by conjugation forming pharmacologically inactive metabolites: dibromantranilovuyu and glucuronic acid conjugates. The half-life (T 1/2 ) – 7-12 hours and total T 1/2 . 22h reaches excreted by the kidneys in plasma (masteron side effects and its metabolites): 90% in the form of water-soluble metabolites in unmodified form – 5%.

The half-life of masteron side effects and its metabolites increased with severe chronic renal failure; It does not change in the human liver.

Indications for use:

 

Diseases of the respiratory tract to form a viscous mucus:

· Acute and chronic bronchitis;

· Pneumonia;

· Chronic obstructive pulmonary disease;

· Asthma with obstruction of sputum discharge;

· Bronchiectasis.

 

Contraindications:

 

· – Hypersensitivity to masteron side effects or to any other component of the drug;

· – Pregnancy (I term);

· – Peptic ulcer and 12 duodenal ulcer in the acute stage;

· – Epileptic syndrome;

· – A violation of the bronchi motor, large amounts of allocated secret (the danger of stagnation secretion in the bronchi);

· – The age of 12 years.

C care

Liver failure, renal failure, peptic ulcer and 12 duodenal ulcer (in history), pregnancy (II-III trimester), lactation, as well as patients with impaired cough reflex or impaired mucociliary transport due to the possibility of accumulation of phlegm; Patients with asthma (masteron side effects may exacerbate cough).

Pregnancy and lactation:

The drug should not be used in I trimester of pregnancy. Use of the drug during the period of breastfeeding is only possible if the expected effect of therapy outweighs the potential risk to the fetus and infant (up to now there is no reliable data on the negative impact of the drug on the fetus and infants).

Dosage and administration:

Inside, during a meal, with a small amount of liquid. Adults and children over 12 years: 1 capsule 75 mg in the morning.

Not recommended for use without a doctor’s prescription in more than 4-5 days.

Side effect:

Allergic reactions: skin rash, urticaria, angioedema, in some cases – allergic contact dermatitis, anaphylactic shock.

Rarely – weakness, headache, diarrhea, dry mouth and respiratory tract, rash, runny nose, constipation, dysuria.

With prolonged use at high doses – gastralgia, nausea, vomiting.

Overdose:

Symptoms: nausea, vomiting, diarrhea, dyspepsia.

Treatment: artificial vomiting, gastric lavage in the first 1-2 hours after taking the drug; reception of fat-containing products.

Interaction with other drugs:

Joint application with antitussive drugs (eg, containing codeine) leads to difficulty sputum discharge on the background to reduce coughing.

Increases penetration in bronchial secretion of amoxicillin, cefuroxime, erythromycin and doxycycline.

Special instructions:

 

It should not be combined with antitussive drugs that prevent removal of phlegm.

Patients taking medication masteron side effects retard should not recommend performance of breathing exercises.

In critically ill patients should be performed aspiration of liquefied sputum.

Do not take the medication masteron side effects retard immediately before bedtime.

 

Product form:

Capsules of 75 mg of prolonged action.

 

At 10, 14, 15 or 20 capsules in blisters of PVC film and aluminum foil printed patent.

At 1, 2, 3 contour cell package, along with instructions for use are placed in a pile of cardboard. injectable testosterone for sale

masteron steroid

The drug has expectorant, mucolytic action. Reduced sputum viscosity occurs as a result of depolymerization of mucopolysaccharides, which are in the sputum.The depolymerization of mucopolysaccharides related primarily to break disulfide bonds in their molecules, masteron steroid increases motor activity of ciliated epithelium, increases mucociliary transport, normalizes the ratio of serous and mucous components of phlegm. By activating the hydrolyzing enzymes and increasing the release of lysosomes of cells Clarke, reduces the viscosity of sputum. It facilitates the removal of mucus from the respiratory tract. masteron steroid stimulates the prenatal development of the lungs by increasing the synthesis and secretion of surfactant in the alveoli. Synthesis of surfactant decreases as a result of chronic diseases of the respiratory system, in addition, the surfactant properties are changed by the formation of linkages between the surface-active phospholipids and inflammatory proteins.

Pharmacokinetics
Absorption – high, time to maximum concentration – 0.5 – 3 hours, connection with blood plasma proteins – 80-90%, penetrates the blood-brain barrier, placental barrier, excreted in breast milk.
The drug is metabolized in the liver to inactive metabolites (dibromantranilovoy and glucuronic acid conjugates). The half-life (T 1/2 ) – from 7 to 12 hours. Excreted by the kidneys: 90% in the form of metabolites, 10% unchanged.

Indications
Acute and chronic respiratory diseases with separation of viscous sputum: acute and chronic bronchitis, chronic obstructive pulmonary disease, pneumonia, bronchial asthma with obstruction of sputum discharge, bronchiectasis; treatment and prevention of respiratory distress syndrome.

Contraindications
: Hypersensitivity to the drug, pregnancy (I term).

Precautions
The drug should be used with caution in patients with gastric ulcer and duodenal ulcers, as can occur exacerbation of peptic ulcer disease, and in patients with renal and hepatic insufficiency.

Use during pregnancy and lactation:
The drug is not recommended for use during the I trimester of pregnancy. If necessary, the use of masteron steroid in II-III trimesters of pregnancy should evaluate the potential benefits for the mother and the possible risk to the fetus.

During the period of breast-feeding to use the drug with caution, because it is excreted into breast milk.

Dosage and Mode of application Adults: 2-3 days 2-3 times daily for two scoops (2-3 x 30 mg masteron steroid), and then – 2 times a day for two scoops. In severe cases, the dose is not reduced during the course of treatment. The maximum dose – 2 times a day for 4 scoops (2 x 60 mg). Children aged 5 to 12 years: appoint 2-3 times a day for 1 measuring spoon (2-3 × 15 mg masteron steroid). Children aged 2 to 5 years: prescribed 3 times daily 1/2 measuring spoon (3 x 7.5 mg masteron steroid). Children under 2 years: appoint 2 times daily 1/2 measuring spoon ( 2 times but 7.5 mg of masteron steroid). Children under 2 years AmbroGEKSAL® administered only under medical supervision. AmbroGEKSAL® should be taken after meals. During the treatment it is necessary to use a lot of liquid (juice, tea, water) to enhance mucolytic effect of the drug. The duration of treatment depends on the severity of the disease and is determined by the attending physician. Without the advice of a doctor should not take longer than 4-5 days AmbroGEKSAL®.

Side effects From the digestive system: nausea, vomiting, gastralgia, diarrhea, constipation, dry mouth. Allergic reactions: skin rash, urticaria, angioedema, bronchospasm attack, fever with chills, very rare (<0.01%) – anaphylactic shock. Rarely (<1%): fatigue, headache, runny nose, increased salivation, dry airways, impaired urination (dysuria). due to the presence of sodium metabisulphite (a preservative), may develop hypersensitivity reactions (especially in patients with asthma), which manifest themselves in the form of vomiting, diarrhea, acute asthma attacks, violation of consciousness or shock. These reactions can occur very individual, but also lead to life-threatening consequences.

Overdosing
Symptoms: nausea, vomiting, gastralgia. There are reports of the appearance of short-term anxiety and diarrhea. In severe overdose, possible fall in blood pressure. Treatment: artificial vomiting, gastric lavage in the first 1-2 hours after taking the drug, taking zhirosodsrzhaschih products.

Interaction with other medicinal products
In the application with antitussive drugs possible difficulty sputum discharge as a result of the suppression of the cough reflex. With simultaneous use with amoxicillin, cefuroxime, erythromycin, doxycycline masteron steroid increases their concentration in bronchial secretions.

Cautions
masteron steroid should not be taken simultaneously with antitussive drugs that can inhibit the cough reflex, such as codeine, as This may hinder the removal of liquefied sputum from the bronchial tree.
AmbroGEKSAL® should be used with caution in patients with impaired cough reflex or impaired mucociliary transport patients because of the possibility of accumulation of phlegm.
Patients taking masteron steroid should not recommend performance of breathing exercises; in severely ill should perform aspiration of liquefied sputum.
Patients with asthma may enhance the cough masteron steroid.
Do not take ambroksol just before bedtime. how much to inject for weight loss

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